Combination of (M)DSC and surface analysis to study the phase behaviour and drug distribution of ternary solid dispersions
Meeus, Joke and Scurr, David J. and Chen, Xinyong and Amssoms, Katie and Davies, Martyn C. and Roberts, Clive J. and Mooter, Guy Van den (2015) Combination of (M)DSC and surface analysis to study the phase behaviour and drug distribution of ternary solid dispersions. Pharmaceutical Research, 32 (4). pp. 1407-1416. ISSN 1573-904X
Purpose: Miscibility of the different compounds that make up a solid dispersion based formulation play a crucial role in the drug release profile and physical stability of the solid dispersion as it defines the phase behaviour of the dispersion. The standard technique to obtain information on phase behaviour of a sample is (modulated) differential scanning calorimetry ((M)DSC). However, for ternary mixtures (M)DSC alone is not sufficient to characterize their phase behaviour and to gain insight into the distribution of the active pharmaceutical ingredient (API) in a two-phased polymeric matrix.
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