Evidence for a novel Kit adhesion domain mediating human mast cell adhesion to structural airway cells
Gough, Kevin C. and Maddison, Ben C. and Shikotra, Aarti and Moiseeva, Elena P. and Yang, Weidong and Jarvis, Shila and Bradding, Peter (2015) Evidence for a novel Kit adhesion domain mediating human mast cell adhesion to structural airway cells. Respiratory Research, 16 . 86/1-86/11. ISSN 1465-9921
Official URL: http://www.respiratory-research.com/content/16/1/86
Background: Human lung mast cells (HLMCs) infiltrate the airway epithelium and airway smooth muscle (ASM) in asthmatic airways. The mechanism of HLMC adhesion to both cell types is only partly defined, and adhesion is not inhibited by function-blocking anti-Kit and anti-stem cell factor (SCF) antibodies. Our aim was to identify adhesion molecules expressed by human mast cells that mediate adhesion to human ASM cells (HASMCs) and human airway epithelial cells.
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