Circulation of prions within dust on a scrapie affected farm
Gough, Kevin C. and Baker, Claire A. and Simmons, Hugh A. and Hawkins, Steve A. and Maddison, Ben C. (2015) Circulation of prions within dust on a scrapie affected farm. Veterinary Research, 46 . p. 40. ISSN 0928-4249
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Official URL: http://www.veterinaryresearch.org/content/46/1/40
Prion diseases are fatal neurological disorders that affect humans and animals. Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs have a direct link to the transmission of disease. Using protein misfolding cyclic amplification we demonstrate that scrapie PrPSc can be detected within circulating dusts that are present on a farm that is naturally contaminated with sheep scrapie. The presence of infectious scrapie within airborne dusts may represent a possible route of infection and illustrates the difficulties that may be associated with the effective decontamination of such scrapie affected premises.
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