Circulation of prions within dust on a scrapie affected farm

Gough, Kevin C. and Baker, Claire A. and Simmons, Hugh A. and Hawkins, Steve A. and Maddison, Ben C. (2015) Circulation of prions within dust on a scrapie affected farm. Veterinary Research, 46 . p. 40. ISSN 0928-4249

This is the latest version of this item.

[img] PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution.
Download (455kB)

Abstract

Prion diseases are fatal neurological disorders that affect humans and animals. Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs have a direct link to the transmission of disease. Using protein misfolding cyclic amplification we demonstrate that scrapie PrPSc can be detected within circulating dusts that are present on a farm that is naturally contaminated with sheep scrapie. The presence of infectious scrapie within airborne dusts may represent a possible route of infection and illustrates the difficulties that may be associated with the effective decontamination of such scrapie affected premises.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: https://doi.org/10.1186/s13567-015-0176-1
Depositing User: Gough, Kevin
Date Deposited: 24 Sep 2015 12:51
Last Modified: 15 Sep 2016 00:10
URI: http://eprints.nottingham.ac.uk/id/eprint/30238

Available Versions of this Item

  • Circulation of prions within dust on a scrapie affected farm. (deposited 24 Sep 2015 12:51) [Currently Displayed]

Actions (Archive Staff Only)

Edit View Edit View