Circulation of prions within dust on a scrapie affected farm

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Gough, Kevin C., Baker, Claire A., Simmons, Hugh A., Hawkins, Steve A. and Maddison, Ben C. (2015) Circulation of prions within dust on a scrapie affected farm. Veterinary Research, 46 . p. 40. ISSN 0928-4249

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Abstract

Prion diseases are fatal neurological disorders that affect humans and animals. Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs have a direct link to the transmission of disease. Using protein misfolding cyclic amplification we demonstrate that scrapie PrPSc can be detected within circulating dusts that are present on a farm that is naturally contaminated with sheep scrapie. The presence of infectious scrapie within airborne dusts may represent a possible route of infection and illustrates the difficulties that may be associated with the effective decontamination of such scrapie affected premises.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/749595
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: https://doi.org/10.1186/s13567-015-0176-1
Depositing User: Gough, Kevin
Date Deposited: 24 Sep 2015 12:51
Last Modified: 04 May 2020 17:06
URI: https://eprints.nottingham.ac.uk/id/eprint/30238

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