A mathematical model of the human metabolic system and metabolic flexibility
Pearson, Taliesin and Wattis, Jonathan A.D. and King, John. R. and MacDonald, Ian A. and Mazzatti, Dawn (2014) A mathematical model of the human metabolic system and metabolic flexibility. Bulletin of Mathematical Biology, 76 (9). pp. 2091-2121. ISSN 0092-8240
In healthy subjects some tissues in the human body display metabolic flexibility, by this we mean the ability for the tissue to switch its fuel source between predominantly carbohydrates in the post prandial state and predominantly fats in the fasted state. Many of the pathways involved with human metabolism are controlled by insulin, and insulin- resistant states such as obesity and type-2 diabetes are characterised by a loss or impairment of metabolic flexibility.
Actions (Archive Staff Only)