Risk factors for wheezing in infants born in Cuba

Venero-Fernandez, S.J., Suarez-Medina, R., Mora-Faife, E.C., Garcia-Garcia, G., Valle-Infante, I., Gomez-Marrero, L., Abreu-Suarez, G., Gonzalez-Valdez, J., Dania Fabro-Ortiz, D., Fundora-Hernandez, H., Venn, A., Britton, J. and Fogarty, Andrew W. (2013) Risk factors for wheezing in infants born in Cuba. QJM: An International Journal of Medicine, 106 (11). pp. 1023-1029. ISSN 1460-2725

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Background: Cuba is a unique country, and despite limited economic development, has an excellent health system. However, the prevalence of asthma symptoms in children in Havana, Cuba, is unusually high.

Aim: As early life exposures are critical to the aetiology of asthma, we have studied environmental influences on the risk of wheezing in Cuban infants.

Design: Cross-sectional study.

Methods: A random sample of 2032 children aged 12–15 months living in Havana was selected for inclusion in the cohort. Data were collected using questionnaires administered by researchers.

Results: Of 2032 infants invited to participate, 1956 (96%) infants provided data. The prevalence of any wheeze was 45%, severe wheeze requiring use of emergency services was 30% and recurrent wheeze on three or more occasions was 20%. The largest adjusted risk factors for any wheeze were presence of eczema [odds ratio (OR) 2.09; 95% confidence interval (CI) 1.48–2.94], family history of asthma (OR 2.05; 95% CI 1.60–2.62), poor ventilation in the house (OR 1.99; 95% CI 1.48–2.67), attendance at nursery (OR 1.78; 95% CI 1.24–2.57), male sex (OR1.52; 95% CI 1.19–1.96) and the number of smokers in the house (P < 0.03 for trend), OR 1.64 (95% CI 1.17–2.31) for three or more smokers in the house compared to no smokers in the household.

Conclusion: We have identified several risk factors for any wheeze in young infants living in modern day Cuba. As the prevalence of smoking in the house is high (51%), intervention studies are required to determine effective strategies to improve infant health.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/719564
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
Identification Number: https://doi.org/10.1093/qjmed/hct143
Depositing User: Johnson, Mrs Alison
Date Deposited: 10 Apr 2014 09:37
Last Modified: 04 May 2020 16:39
URI: https://eprints.nottingham.ac.uk/id/eprint/2940

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