The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study

Enocson, Alexandra and Hubbard, Richard and McKeever, Tricia and Russell, Nigel and Byrne, Jennifer and Das-Gupta, Emma and Watson, Lynne and Fogarty, Andrew W. (2013) The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study. BMC Pulmonary Medicine, 13 (Januar). 6/1-6/6. ISSN 1471-2466

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Abstract

Background: No studies have investigated the immediate impact of receiving an allogeneic hematopoietic stem cell transplant (HSCT) on pulmonary inflammation or lung function.

Methods: Using a prospective study design, we quantified the changes in these outcome measures in eligible adult individuals in the first six months after receiving an allogeneic hematopoietic stem cell transplant.

Results: Between January 2007 and December 2008, 72 patients were eligible to participate in the cohort, and of these 68 (94%) were included in the study. Compared to baseline, pulmonary inflammation as measured by exhaled nitric oxide increased after receiving a HSCT with the largest increment seen at three months (+6.0ppb, 95%CI: +0.4 to +11.5), and this was sustained at six months. Percent predicted forced expiratory volume in one second decreased over the same period, with the largest decrease observed at six weeks (−5.9%, 95% CI: -8.9 to −2.9), and this was also sustained over a six month period. Similar associations were observed for FVC. A larger increase in exhaled nitric oxide from baseline at six weeks and three months may be associated with decreased mortality (p=0.06, p=0.04 respectively).

Conclusion: Our data demonstrate that recipients of an allogeneic HSCT experience an increase in biomarkers of pulmonary inflammation and a decrease in lung function in the first six months after the procedure. If independently validated in other study populations, these observations could have potential as a prognostic biomarker for this patient group.

Item Type: Article
Keywords: Lung function, Inflammation, Haematopoietic transplant
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences
Depositing User: Johnson, Mrs Alison
Date Deposited: 10 Apr 2014 10:39
Last Modified: 13 Sep 2016 20:51
URI: http://eprints.nottingham.ac.uk/id/eprint/2934

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