Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells

Salazar, Fabian and Ghaemmaghami, Amir M. (2013) Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells. Frontiers in Immunology, 4 . 356/1-356/10. ISSN 1664-3224

[img] PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution.
Download (1MB)

Abstract

Allergy is an exacerbated response of the immune system against non-self-proteins called allergens and is typically characterized by biased type-2 T helper cell and deleterious IgE mediated immune responses. The allergic cascade starts with the recognition of allergens by antigen presenting cells, mainly dendritic cells (DCs), leading to Th2 polarization, switching to IgE production by B cells, culminating in mast cell sensitization and triggering. DCs have been demonstrated to play a crucial role in orchestrating allergic diseases. Using different C-type lectin receptors DCs are able to recognize and internalize a number of allergens from diverse sources leading to sensitization. Furthermore, there is increasing evidence highlighting the role of epithelial cells in triggering and modulating immune responses to allergens. As well as providing a physical barrier, epithelial cells can interact with allergens and influence DCs behavior through the release of a number of Th2 promoting cytokines. In this review we will summarize current understanding of how allergens are recognized by DCs and epithelial cells and what are the consequences of such interaction in the context of allergic sensitization and downstream events leading to allergic inflammation. Better understanding of the molecular mechanisms of allergen recognition and associated signaling pathways could enable developing more effective therapeutic strategies that target the initial steps of allergic sensitization hence hindering development or progression of allergic diseases.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Molecular Medical Sciences > Immunology
Identification Number: https://doi.org/10.3389/fimmu.2013.00356
Depositing User: Johnson, Mrs Alison
Date Deposited: 10 Apr 2014 12:58
Last Modified: 13 Sep 2016 16:46
URI: http://eprints.nottingham.ac.uk/id/eprint/2924

Actions (Archive Staff Only)

Edit View Edit View