The potential utility of stem cells in the treatment of congenital heart disease
Davies, Ben (2009) The potential utility of stem cells in the treatment of congenital heart disease. PhD thesis, University of Nottingham.
Non-ischaemic right ventricular dysfunction and cardiac failure is a source of considerable morbidity in children with congenital heart disease. Despite an increasing body of evidence suggesting that the intrinsic regenerative capacity of the heart can be encouraged by stimulation of resident cardiac stem cells or the transplantation of extracardiac progenitor cells, cell transplantation has not previously been studied in the paediatric setting where enhancing the function of the ventricle in response to supraphysiological workloads might be beneficial.
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