Modelling angiogenesis in three dimensions

Parsonson, Louis (2015) Modelling angiogenesis in three dimensions. PhD thesis, University of Nottingham.

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Abstract

The process through which new blood vessels are formed within the body is known as angiogenesis. An essential part of our survival, it has also been implicated more recently in many diseases both in terms of induced growth, and abnormal vascular structure.

Angiogenesis is characterized as two processes, the development of a vascular network during embryonic growth and the production of new blood vessels. This work focuses on the latter, and seeks to develop a robust, three-dimensional model for simulating blood vessel growth and the attendant processes of blood flow and mass transfer within the simulated system. A system was developed which utilises medical imaging scan data (specifically, MicroCT) as the initial conditions from which a network of vessels is grown. This is combined with GPU accelerated simulations of fluid dynamics, with the intention of providing a technique for future use in predictive medicine and therapeutic simulation.

Item Type: Thesis (University of Nottingham only) (PhD)
Supervisors: Bai, Li
Keywords: Angiogenesis simulation, three dimensions, fluid dynamics, blood flow, diffusion
Subjects: Q Science > QA Mathematics > QA 75 Electronic computers. Computer science
Q Science > QP Physiology
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Faculties/Schools: UK Campuses > Faculty of Science > School of Computer Science
Item ID: 29075
Depositing User: Parsonson, Louis
Date Deposited: 08 Dec 2015 09:28
Last Modified: 17 Sep 2016 08:44
URI: http://eprints.nottingham.ac.uk/id/eprint/29075

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