An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells
Sharquie, Inas K. and Al-Ghouleh, Abeer and Fitton, Patricia and Clark, Mike R. and Armour, Kathryn L. and Sewell, Herb F. and Shakib, Farouk and Ghaemmaghami, Amir M. (2013) An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells. BMC Immunology, 14 (Decemb). 12/1-12/12. ISSN 1471-2172
Official URL: http://www.biomedcentral.com/1471-2172/14/54
Background: Allergen recognition by dendritic cells (DCs) is a key event in the allergic cascade leading to production of IgE antibodies. C-type lectins, such as the mannose receptor and DC-SIGN, were recently shown to play an important role in the uptake of the house dust mite glycoallergen Der p 1 by DCs. In addition to mannose receptor (MR) and DC-SIGN the high and low affinity IgE receptors, namely FcϵRI and FcϵRII (CD23), respectively, have been shown to be involved in allergen uptake and presentation by DCs.
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