The interplay between tissue growth and scaffold degradation in engineered tissue constructs
O'Dea, Reuben D. and Osborne, J.M. and El Haj, A. and Byrne, H.M. and Waters, S.L. (2013) The interplay between tissue growth and scaffold degradation in engineered tissue constructs. Journal of Mathematical Biology, 67 (5). pp. 1199-1225. ISSN 0303-6812
In vitro tissue engineering is emerging as a potential tool to meet the high demand for replacement tissue, caused by the increased incidence of tissue degeneration and damage. A key challenge in this field is ensuring that the mechanical properties of the engineered tissue are appropriate for the in vivo environment. Achieving this goal will require detailed understanding of the interplay between cell proliferation, extracellular matrix (ECM) deposition and scaffold degradation.
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