The influence of bioreactor geometry and the mechanical environment on engineered tissues
Osborne, J.M. and O'Dea, Reuben D. and Whiteley, J.P. and Byrne, H.M. and Waters, S.L. (2010) The influence of bioreactor geometry and the mechanical environment on engineered tissues. Journal of Biomechanical Engineering, 132 (5). 051006/1-051006/12. ISSN 0148-0731
A three phase model for the growth of a tissue construct within a perfusion bioreactor is examined. The cell population (and attendant extracellular matrix), culture medium and porous scaffold are treated as distinct phases. The bioreactor system is represented by a two-dimensional channel containing a cell-seeded rigid porous scaffold (tissue construct) which is perfused with culture medium. Through the prescription of appropriate functional forms for cell proliferation and extracellular matrix deposition rates, the model is used to compare the influence of cell density-, pressure- and culture medium shear stress-regulated growth on the composition of the engineered tissue.
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