First passage times in integrate-and-fire neurons with stochastic thresholds

Braun, Wilhelm and Matthews, Paul C. and Thul, Ruediger (2015) First passage times in integrate-and-fire neurons with stochastic thresholds. Physical Review E, 91 . 052701/1-052701/7. ISSN 1539-3755

This is the latest version of this item.

[img] PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution.
Download (730kB)


We consider a leaky integrate--and--fire neuron with deterministic subthreshold dynamics and a firing threshold that evolves as an Ornstein-Uhlenbeck process. The formulation of this minimal model is motivated by the experimentally observed widespread variation of neural firing thresholds. We show numerically that the mean first passage time can depend non-monotonically on the noise amplitude. For sufficiently large values of the correlation time of the stochastic threshold the mean first passage time is maximal for non-vanishing noise. We provide an explanation for this effect by analytically transforming the original model into a first passage time problem for Brownian motion. This transformation also allows for a perturbative calculation of the first passage time histograms. In turn this provides quantitative insights into the mechanisms that lead to the non-monotonic behaviour of the mean first passage time. The perturbation expansion is in excellent agreement with direct numerical simulations. The approach developed here can be applied to any deterministic subthreshold dynamics and any Gauss-Markov processes for the firing threshold. This opens up the possibility to incorporate biophysically detailed components into the subthreshold dynamics, rendering our approach a powerful framework that sits between traditional integrate-and-fire models and complex mechanistic descriptions of neural dynamics.

Item Type: Article
Additional Information: Copyright 2015 American Physical Society
Keywords: Neurons, Neural stochasticity
Schools/Departments: University of Nottingham UK Campus > Faculty of Science > School of Mathematical Sciences
Identification Number:
Related URLs:
Depositing User: Braun, Wilhelm
Date Deposited: 08 May 2015 09:14
Last Modified: 18 Sep 2016 13:41

Available Versions of this Item

  • First passage times in integrate-and-fire neurons with stochastic thresholds. (deposited 08 May 2015 09:14) [Currently Displayed]

Actions (Archive Staff Only)

Edit View Edit View