Swap70b acts downstream of Wnt11 signalling to regulate zebrafish convergence and extension cell movements
Xu, Xiaoou (2015) Swap70b acts downstream of Wnt11 signalling to regulate zebrafish convergence and extension cell movements. PhD thesis, University of Nottingham.
During vertebrate gastrulation, convergence and extension (CE) cell movements narrow the body axis medial-laterally (convergence) and extend it anterior-posteriorly (extension). In zebrafish, Wnt11 (silberblick) and Wnt5b (pipetail) mutants exhibited widening and shortening of the body axes characteristic for CE cell movements defects during gastrulation. It was subsequently reported that Wnt signalling resulted in activation of Rho GTPases and rearrangements of the F-actin cytoskeleton, establishing that CE cell movements are regulated through the non canonical Wnt/PCP pathway. Rho GTPases are activated by guanine nucleotide exchange factors (GEFs) and it was recently found that Def6a, a GEF for Rac1, Cdc42, and RhoA, was the downstream target of Wnt5b signalling.
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