The role of very long chain fatty acids in Arabidopsis growth and development
Seamons, Laura Elizabeth (2015) The role of very long chain fatty acids in Arabidopsis growth and development. PhD thesis, University of Nottingham.
Very long chain fatty acids (VLCFAs) are essential to Arabidopsis growth and development. VLCFAs are found in sphingolipids, glycerophospholipids, triacylglycerols, suberin and cuticular waxes. VLCFAs are synthesized by the addition of 2 carbons from malonyl-CoA to pre-existing acyl-CoAs to produce chain lengths of greater than 18 carbon atoms. VLCFA synthesis involves four consecutive reactions that are catalysed by the microsomal Fatty Acid Elongase. In Arabidopsis the first reaction is catalysed by one of 21 different Keto-CoA Synthases (KCS) with diverse levels of expression and overlapping tissue specificities. The other three enzymes are ubiquitously expressed throughout the plant, and form the core components of the elongase.
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