Investigating the association between germ line specification and sequence evolution in vertebrates
Evans, Teri (2015) Investigating the association between germ line specification and sequence evolution in vertebrates. PhD thesis, University of Nottingham.
Within vertebrates the primordial germ cells (PGCs) can either be induced by embryonic signals (known as epigenesis), or predetermined by maternally deposited germ plasm (preformation). Epigenesis is known to be the ancestral mechanism, while preformation has evolved multiple times. Epigenesis has been proposed to enforce a developmental constraint on the evolution of somatic structures that is released in species which acquired preformation. In accordance with this hypothesis, the mesoderm gene regulatory network is conserved between urodeles and mammals, which have retained epigenesis, but has diverged in anurans (preformation). An increase in speciation has also been shown in vertebrates which have acquired preformation. Our aims were to investigate whether the mode of PGC specification associates with the molecular evolution of protein-coding genes.
Actions (Archive Staff Only)