The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring

Wright, Thomas and King, Madeleine and Davey, William and Langley-Evans, Simon C. and Voigt, Jörg-Peter (2014) The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring. British Journal of Nutrition, 112 . pp. 1933-1937. ISSN 0007-1145

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Abstract

There is increasing evidence that hyperenergetic diets impact on memory in rodents. However, it is largely unknown how diets, such as a cafeteria diet (CD), that mimic a Western diet act on learning and memory, in particular when fed during early stages of development. Here, we fed lactating dams a cafeteria diet and exposed both male and female offspring to a novel object discrimination (NOD) task, a two-trial test of recognition memory in which rats exposed to two identical objects during a training/familiarisation trial can discriminate a novel from a familiar object during the subsequent choice trial. The choice trial was performed following inter-trial interval (ITI) delays of up to 4 h. Maternal diet did not impact on exploration of the objects by either sex during the familiarisation trial. Control males discriminated the novel from the familiar object indicating intact memory with an ITI of 1h, but not 2 or 4h. CD delayed this natural forgetting in male rats such that discrimination was also evident after a 2h ITI. In contrast, control females exhibited discrimination following both 1 and 2h ITIs, but CD impaired performance. In summary, the present study shows that maternal exposure to CD programmes NOD in the adult. In better performing females dietary programming interferes with NOD whereas NOD was improved in males after lactational CD feeding.

Item Type: Article
Additional Information: Copyright Cambridge University Press.
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Biosciences
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: https://doi.org/10.1017/S0007114514003134
Depositing User: Langley-Evans, Simon
Date Deposited: 17 Mar 2015 14:46
Last Modified: 10 Dec 2016 06:28
URI: http://eprints.nottingham.ac.uk/id/eprint/28477

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