Catalytic activation of nitriles towards nucleophilic addition
Lester, Roy P. (2015) Catalytic activation of nitriles towards nucleophilic addition. PhD thesis, University of Nottingham.
The work presented in this thesis is focused on the development of a multifaceted approach to the catalytic activation of nitriles. To develop a versatile method for catalytic nitrile activation two probes were utilised; i) the development of a direct synthesis of allylic amides from the corresponding allylic alcohol and nitrile using a commercial platinum salt, together with a detailed mechanistic investigation into the process, ii) the direct synthesis of 2-bezoxazole from the corresponding 2-aminophenol and nitrile with the aid of a commercial platinum salt as well as the use of alcoholic solvents. In addition to nitrile activation a preliminary study on the application and further functionisation of 2-trichlorobenzoxazoles was undertaken.
Actions (Archive Staff Only)