A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms

Kadam, Rameshwar U. and Bergmann, Myriam and Hurley, Matthew and Garg, Divita and Cacciarini, Martina and Swiderska, Magdalena A. and Nativi, Cristina and Sattler, Michael and Smyth, Alan R. and Williams, Paul and Cámara, Miguel and Stocker, Achim and Darbre, Tamis and Reymond, Jean-Louis (2011) A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms. Angewandte Chemie International Edition, 50 (45). pp. 10631-10635. ISSN 1433-7851

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Abstract

Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galactose can provide additional contacts to the lectin and also has an effect on the interaction.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences
Depositing User: Wahid, Ms. Haleema
Date Deposited: 04 Apr 2014 14:01
Last Modified: 12 May 2016 02:51
URI: http://eprints.nottingham.ac.uk/id/eprint/2843

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