The effect of hypoxia and reoxygenation on STAT3 regulation in potential cardiomyocyte models
Evans, Emma Louise (2012) The effect of hypoxia and reoxygenation on STAT3 regulation in potential cardiomyocyte models. PhD thesis, University of Nottingham.
Cardiomyocyte apoptosis is an important contributory factor towards the progression of ischaemic heart disease. Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor has that been implicated in normal heart development and function. Most interestingly, STAT3 also appears to play a role in cardioprotection, including hypoxic preconditioning. In this thesis the levels and activities of ST A T3 were measured in response to hypoxic insult in primary rat cardiomyocytes (RCMs) and two cardiomyocyte cell lines (H9c2 and P19CL6 cells). P19CL6 cells were extremely sensitive to hypoxia-induced apoptosis whereas RCMs and H9c2 cells were highly resistant.
Actions (Archive Staff Only)