Neural primacy of the salience processing system in schizophrenia

Palaniyappan, Lena and Simmonite, M. and White, T.P. and Liddle, E.B. and Liddle, P.F. (2013) Neural primacy of the salience processing system in schizophrenia. Neuron, 79 (4). pp. 814-828. ISSN 0896-6273

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Abstract

For effective information processing, two large-scale distributed neural networks appear to be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (DLPFC) and a salience system anchored on the anterior insula. Aberrant interaction among distributed networks is a feature of psychiatric disorders such as schizophrenia. We used whole-brain Granger causal modeling using resting fMRI and observed a significant failure of both the feedforward and reciprocal influence between the insula and the DLPFC in schizophrenia. Further, a significant failure of directed influence from bilateral visual cortices to the insula was also seen in patients. These findings provide compelling evidence for a breakdown of the salience-execution loop in the clinical expression of psychosis. In addition, this offers a parsimonious explanation for the often-observed “frontal inefficiency,” the failure to recruit prefrontal system when salient or novel information becomes available in patients with schizophrenia.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Medical Education Unit and Medical Courses Office
Depositing User: Wahid, Ms. Haleema
Date Deposited: 02 Apr 2014 11:09
Last Modified: 13 Sep 2016 13:26
URI: http://eprints.nottingham.ac.uk/id/eprint/2826

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