Importance of Toxin A, Toxin B, and CDT in virulence of an epidemic Clostridium difficile strain

Kuehne, Sarah A. and Collery, Mark M. and Kelly, Michelle L. and Cartman, Stephen T. and Cockayne, Alan and Minton, Nigel P. (2014) Importance of Toxin A, Toxin B, and CDT in virulence of an epidemic Clostridium difficile strain. Journal of Infectious Diseases, 209 (1). pp. 83-86. ISSN 0022-1899

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Abstract

Clostridium difficile infection is the main cause of healthcare-acquired diarrhea in the developed world. In addition to the main virulence factors toxin A and B, epidemic, PCR Ribotype 027 strains, such as R20291, produce a third toxin, CDT. To develop effective medical countermeasures, it is important to understand the importance of each toxin. Accordingly, we created all possible combinations of isogenic toxin mutants of R20291 and assessed their virulence. We demonstrated that either toxin A or toxin B alone can cause fulminant disease in the hamster infection model and present tantalizing data that C. difficile toxin may also contribute to virulence.

Item Type: Article
Keywords: Clostridium difficile infection; TcdA; TcdB; pathogenesis; CDT.
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Nottingham Digestive Diseases Centre
Depositing User: Chamberlain, Mr Dick
Date Deposited: 02 Apr 2014 10:25
Last Modified: 15 Sep 2016 15:07
URI: http://eprints.nottingham.ac.uk/id/eprint/2815

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