Importance of Toxin A, Toxin B, and CDT in virulence of an epidemic Clostridium difficile strain

Kuehne, Sarah A., Collery, Mark M., Kelly, Michelle L., Cartman, Stephen T., Cockayne, Alan and Minton, Nigel P. (2013) Importance of Toxin A, Toxin B, and CDT in virulence of an epidemic Clostridium difficile strain. Journal of Infectious Diseases, 209 (1). pp. 83-86. ISSN 1537-6613

Full text not available from this repository.

Abstract

Clostridium difficile infection is the main cause of healthcare-acquired diarrhea in the developed world. In addition to the main virulence factors toxin A and B, epidemic, PCR Ribotype 027 strains, such as R20291, produce a third toxin, CDT. To develop effective medical countermeasures, it is important to understand the importance of each toxin. Accordingly, we created all possible combinations of isogenic toxin mutants of R20291 and assessed their virulence. We demonstrated that either toxin A or toxin B alone can cause fulminant disease in the hamster infection model and present tantalizing data that C. difficile toxin may also contribute to virulence.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/717174
Keywords: Clostridium difficile infection; TcdA; TcdB; pathogenesis; CDT.
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Nottingham Digestive Diseases Centre
Identification Number: https://doi.org/10.1093/infdis/jit426
Depositing User: Chamberlain, Mr Dick
Date Deposited: 02 Apr 2014 10:25
Last Modified: 04 May 2020 16:38
URI: https://eprints.nottingham.ac.uk/id/eprint/2815

Actions (Archive Staff Only)

Edit View Edit View