The molecular mechanism of insulin action in human theca and adipocyte cells in polycycstic ovarian syndrome
Cadagan, David (2013) The molecular mechanism of insulin action in human theca and adipocyte cells in polycycstic ovarian syndrome. PhD thesis, University of Nottingham.
PCOS is one of the leading causes of infertility worldwide affecting 1 in 10 women of a reproductive age. One of the fundamental abnormalities in women with PCOS can be seen within hormonal irregularities, which may include hyperandrogenemia hyperinsulinemia and hyper secretion of luteinising hormone (LH); and it is hypothesised that a defect in steroid secreting ovarian theca cells is involved due to their contribution in non-PCOS hormonal synthesis.
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