Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer

Storr, Sarah J. and Safuan, Sabreena and Woolston, Caroline M. and Abdel-Fatah, Tarek and Deen, Suha and Chan, Stephen Y. and Martin, Stewart G. (2012) Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. Journal of Cellular and Molecular Medicine, 16 (10). pp. 2422-2428. ISSN 1582-1838

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Abstract

Ovarian cancer is routinely treated with surgery and platinum-based chemotherapy. Resistance is a major obstacle in the efficacy of this chemotherapy

regimen and the ability to identify those patients at risk of developing resistance is of considerable clinical importance. The expression of

calpain-1, calpain-2 and calpastatin were determined using standard immunohistochemistry on a tissue microarray of 154 primary ovarian carcinomas

from patients subsequently treated with platinum-based adjuvant chemotherapy. High levels of calpain-2 expression was significantly associated

with platinum resistant tumours (P = 0.031). Furthermore, high expression of calpain-2 was significantly associated with progression-free

(P = 0.049) and overall survival (P = 0.006) in this cohort. The association between calpain-2 expression and overall survival remained significant

in multivariate analysis accounting for tumour grade, stage, optimal debulking and platinum sensitivity (hazard ratio = 2.174; 95% confidence

interval = 1.144–4.130; P = 0.018). The results suggest that determining calpain-2 expression in ovarian carcinomas may allow prognostic stratification

of patients treated with surgery and platinum-based chemotherapy. The findings of this study warrant validation in a larger clinical cohort.

Item Type: Article
Additional Information: Published source must be acknowledged including article DOI
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Molecular Medical Sciences
Depositing User: de Sousa, Mrs Shona
Date Deposited: 01 Apr 2014 10:13
Last Modified: 15 Sep 2016 23:15
URI: http://eprints.nottingham.ac.uk/id/eprint/2786

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