Activation of the transcription factor NF-kB by Campylobacter jejuni
Alsayeqh, Abdullah Fayez (2007) Activation of the transcription factor NF-kB by Campylobacter jejuni. PhD thesis, University of Nottingham.
Campylobacter is currently the most frequently isolated food-borne bacterial pathogen worldwide. Infections caused by C. jejuni may be self-limiting enteritis or chronic conditions such as Guillain-Barre' syndrome (GBS). Although the mechanisms by which C. jejuni causes disease are not clearly understood, the activation of the transcription factor NF-KB, which controls pro-inflammatory responses, is thought to be an important contributing mechanism for initiating the host's immune responses to C. jejuni infection. Signaling pathways leading to NF-KB by pathogens and/or their products include transmembrane Toll-like receptors (TLRs) and intracellular receptors nucleotide-binding oligomerization domain proteins (NODs). This study was carried out to: 1) investigate NF-KB activation by C. jejuni, 2) provide structural details regarding the NF-KB activating component(s) in C. jejuni boiled cell extract (BeE) and 3) investigate the role of TLRs (TLR2 and TLR4) and NODs (NODI and NOD2) in mediating NF-KB activation by C. jejuni.
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