Supercritical fluid technology for gastroretentive formulations
Ahmed, Elizabeth Hannah (2013) Supercritical fluid technology for gastroretentive formulations. PhD thesis, University of Nottingham.
The oral route for drug administration offers an efficient and convenient method for drug delivery. However, there is an assortment of drugs which exhibit narrow absorption windows in the upper small intestine and as a result demonstrate limited bioavailabilities. One approach in the improvement of bioavailability in these cases is to retain the delivery system proximal to the absorption window for a prolonged period of time. Although controlled release products are widely available on the market, marketed gastroretentive systems remain elusive.
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