Study of NAP adsorption and assembly on the surface of HOPG

Korolkov, Vladimir V. and Allen, Stephanie and Roberts, Clive J. and Gozes, Illana and Tendler, Saul J.B. (2014) Study of NAP adsorption and assembly on the surface of HOPG. Peptides, 62 . pp. 55-58. ISSN 0196-9781

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NAP is an octapeptide that has demonstrated a neuroprotective/therapeutic efficacy at very low concentrations in preclinical studies and in a number of clinical trials. Yet little is known about its structural organization at low concentrations. Here, we have employed atomic force microscopy to investigate NAP peptide assembly on graphite in aqueous media at nanomolar concentration. High spatial resolution scans of NAP assemblies reveal their fine structure with clearly resolved single NAP units. This observation leads us to conclude that NAP molecules do not form complex self-assembled structures at nanomolar concentration when adsorbed on graphite surface.

Item Type: Article
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Peptides. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Peptides, 58 (2014), doi: 10.1016/j.peptides.2014.09.017
Keywords: NAP; Atomic Force Microscopy; davunetide; adsorption; peptides
Schools/Departments: University of Nottingham UK Campus > Faculty of Science > School of Pharmacy
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Depositing User: Tendler, Saul
Date Deposited: 24 Oct 2014 10:45
Last Modified: 13 Sep 2016 15:07

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