Study of NAP adsorption and assembly on the surface of HOPG

Tools

Korolkov, Vladimir V., Allen, Stephanie, Roberts, Clive J., Gozes, Illana and Tendler, Saul J.B. (2014) Study of NAP adsorption and assembly on the surface of HOPG. Peptides, 62 . pp. 55-58. ISSN 0196-9781

Full text not available from this repository.

Abstract

NAP is an octapeptide that has demonstrated a neuroprotective/therapeutic efficacy at very low concentrations in preclinical studies and in a number of clinical trials. Yet little is known about its structural organization at low concentrations. Here, we have employed atomic force microscopy to investigate NAP peptide assembly on graphite in aqueous media at nanomolar concentration. High spatial resolution scans of NAP assemblies reveal their fine structure with clearly resolved single NAP units. This observation leads us to conclude that NAP molecules do not form complex self-assembled structures at nanomolar concentration when adsorbed on graphite surface.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/735047
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Peptides. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Peptides, 58 (2014), doi: 10.1016/j.peptides.2014.09.017
Keywords: NAP; Atomic Force Microscopy; davunetide; adsorption; peptides
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: 10.1016/j.peptides.2014.09.017
Depositing User: Tendler, Saul
Date Deposited: 24 Oct 2014 10:45
Last Modified: 04 May 2020 16:53
URI: https://eprints.nottingham.ac.uk/id/eprint/27680

Actions (Archive Staff Only)

Edit View Edit View