Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study

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Forrester, Doug L., Knox, Alan J., Smyth, Alan R. and Fogarty, Andrew W. (2013) Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study. Journal of Cystic Fibrosis, 12 (3). pp. 284-289. ISSN 1873-5010

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Abstract

Background

Body habitus differences may explain some of the variation in lung function between individuals with cystic fibrosis (CF). We tested the hypothesis that measures of lean muscle mass and obesity are independently associated with lung function in CF.

Methods

Cross-sectional study design using UK CF registry data from 2096 clinically stable adults.

Results

Serum creatinine and BMI were positively and independently associated with FEV1 and FVC. One standard deviation increment in serum creatinine was associated with an FEV1 increase of 171 ml (95% confidence intervals CI: + 116 to + 227 ml) in males and 90 ml (95% CI: + 46 to + 133 ml) in females. Compared to the reference group of 20–24.9 kg/m2, those with a BMI < 20 kg/m2 had lower FEV1 with values of − 642 ml (95%CI: − 784 to − 500 ml) for males and − 468 ml (95%CI: − 564 to − 372 ml) for females.

Conclusions

Prospective studies and controlled trials are required to ascertain if these associations have therapeutic potential in modifying disease progression.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/1002123
Keywords: Body mass index; Lung function; Muscle; Cystic fibrosis
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Respiratory Medicine
Identification Number: 10.1016/j.jcf.2012.08.008
Depositing User: Liu, Mr Zhenxing
Date Deposited: 27 Mar 2014 09:16
Last Modified: 04 May 2020 20:19
URI: https://eprints.nottingham.ac.uk/id/eprint/2712

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