Hydrodynamic modelling of protein conformation in solution: ELLIPS and HYDRO

de la Torre, José García and Harding, Stephen E. (2013) Hydrodynamic modelling of protein conformation in solution: ELLIPS and HYDRO. Biophysical Reviews, 5 (2). pp. 195-206. ISSN 1867-2450

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Abstract

The last three decades has seen some important

advances in our ability to represent the conformation of

proteins in solution on the basis of hydrodynamic measurements.

Advances in theoretical modeling capabilities have

been matched by commensurate advances in the precision of

hydrodynamic measurements. We consider the advances in

whole-body (simple ellipsoid-based) modeling—still useful

for providing an overall idea of molecular shape, particularly

for those systems where only a limited amount of data is

available—and outline the ELLIPS suite of algorithms

which facilitates the use of this approach. We then focus

on bead modeling strategies, particularly the surface or

shell–bead approaches and the HYDRO suite of algorithms.

We demonstrate how these are providing great insights into

complex issues such as the conformation of immunoglobulins

and other multi-domain complexes.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Science > School of Biosciences
University of Nottingham UK Campus > Faculty of Science > School of Biosciences > Division of Food Sciences
Identification Number: https://doi.org/10.1007/s12551-013-0102-6
Depositing User: de Sousa, Mrs Shona
Date Deposited: 26 Mar 2014 13:15
Last Modified: 20 Sep 2016 03:12
URI: http://eprints.nottingham.ac.uk/id/eprint/2673

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