Mathematical modeling of genome replication

Retkute, Renata and Nieduszynski, Conrad A. and Moura, Alessandro de (2012) Mathematical modeling of genome replication. Physical Review E, 86 . 031916/1-031916/15. ISSN 1539-3755

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Abstract

Eukaryotic DNA replication is initiated from multiple sites on the chromosome, but little is known about the global and local regulation of replication. We present a mathematical model for the spatial dynamics of DNA replication, which offers insight into the kinetics of replication in different types of organisms. Most biological experiments involve average quantities over large cell populations (typically >107 cells) and therefore can mask the cell-to-cell variability present in the system. Although the model is formulated in terms of a population of cells, using mathematical analysis we show that one can obtain signatures of stochasticity in individual cells from averaged quantities. This work generalizes the result by Retkute et al. [Phys. Rev. Lett. 107, 068103 (2011)] to a broader set of parameter regimes.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Biology
Identification Number: https://doi.org/10.1103/PhysRevE.86.031916
Depositing User: Liu, Mr Zhenxing
Date Deposited: 01 Apr 2014 07:59
Last Modified: 09 Sep 2016 11:44
URI: http://eprints.nottingham.ac.uk/id/eprint/2495

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