Heavy and light roles: myosin in the morphogenesis of the heart

England, Jennifer and Loughna, Siobhan (2013) Heavy and light roles: myosin in the morphogenesis of the heart. Cellular and Molecular Life Science, 70 (7). pp. 1221-1239. ISSN 1420-682X

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Abstract

Myosin is an essential component of cardiac muscle, from the onset of cardiogenesis through to the adult heart. Although traditionally known for its role in energy transduction and force development, recent studies

suggest that both myosin heavy-chain and myosin lightchain

proteins are required for a correctly formed heart.

Myosins are structural proteins that are not only expressed

from early stages of heart development, but when mutated

in humans they may give rise to congenital heart defects.

This review will discuss the roles of myosin, specifically

with regards to the developing heart. The expression of

each myosin protein will be described, and the effects that

altering expression has on the heart in embryogenesis in

different animal models will be discussed. The human

molecular genetics of the myosins will also be reviewed.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Biomedical Sciences
Identification Number: https://doi.org/10.1007/s00018-012-1131-1
Depositing User: de Sousa, Mrs Shona
Date Deposited: 26 Mar 2014 14:17
Last Modified: 13 Sep 2016 17:32
URI: http://eprints.nottingham.ac.uk/id/eprint/2453

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