Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects

Chaddock, G. and Lam, C. and Hoad, C.L. and Costigan, C. and Cox, E.F. and Placidi, E. and Thexton, I. and Wright, J. and Blackshaw, P.E. and Perkins, A.C. and Marciani, Luca and Gowland, P.A. and Spiller, Robin C. (2014) Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects. Neurogastroenterology and Motility, 26 (2). pp. 205-214. ISSN 1350-1925

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Abstract

Background:

Colonic transit tests are used to manage patients with Functional Gastrointestinal Disorders. Some tests used expose patients to ionizing radiation. The aim of this study was to compare novel magnetic resonance imaging (MRI) tests for measuring orocecal transit time (OCTT) and whole gut transit time (WGT), which also provide data on colonic volumes.

Methods:

21 healthy volunteers participated. Study 1: OCTT was determined from the arrival of the head of a meal into the cecum using MRI and the Lactose Ureide breath test (LUBT), performed concurrently. Study 2: WGT was assessed using novel MRI marker capsules and radio-opaque markers (ROMs), taken on the same morning. Studies were repeated 1 week later.

Key Results:

OCTT measured using MRI and LUBT was 225 min (IQR 180–270) and 225 min (IQR 165–278), respectively, correlation rs = 0.28 (ns). WGT measured using MRI marker capsules and ROMs was 28 h (IQR 4–50) and 31 h ± 3 (SEM), respectively, correlation rs = 0.85 (p < 0.0001). Repeatability assessed using the intraclass correlation coefficient (ICC) was 0.45 (p = 0.017) and 0.35 (p = 0.058) for MRI and LUBT OCTT tests. Better repeatability was observed for the WGT tests, ICC being 0.61 for the MRI marker capsules (p = 0.001) and 0.69 for the ROM method (p < 0.001) respectively.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine
Depositing User: Snowden, Ms Diane
Date Deposited: 22 Apr 2014 12:54
Last Modified: 13 Sep 2016 16:45
URI: http://eprints.nottingham.ac.uk/id/eprint/2334

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