Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework

Timofeeva, Yulia and Lord, Gabriel and Coombes, Stephen (2005) Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework.

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Abstract

The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we develop a computational framework that allows the study of multiple spiking events in a network of such spines embedded in a simple one-dimensional cable. This system is shown to support saltatory waves as a result of the discrete distribution of spines. Moreover, we demonstrate one of the ways to incorporate noise into the spine-head whilst retaining computational tractability of the model. The SDS model sustains a variety of propagating patterns.

Item Type:Article
Uncontrolled Keywords:spike-diffuse-spike, dendritic spines, saltatory waves, noise
Schools/Departments:Faculty of Science > School of Mathematical Sciences
ID Code:210
Deposited By:Coombes, Prof Stephen
Deposited On:24 Oct 2005
Last Modified:24 Jun 2011 15:29

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