Simulating the dynamics of T cell subsets throughout the lifetime

Foan, Stephanie and Jackson, Andrew M. and Spendlove, Ian and Aickelin, Uwe (2011) Simulating the dynamics of T cell subsets throughout the lifetime. In: Artificial immune systems: 10th international conference, ICARIS 2011, Cambridge, UK, July 18-21, 2011: proceedings. Lecture notes in computer science (6825). Springer, Heidelberg, pp. 71-76. ISBN 9783642223716

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Abstract

It is widely accepted that the immune system undergoes age-related changes correlating with increased disease in the elderly. T cell subsets have been implicated. The aim of this work is firstly to implement and validate a simulation

of T regulatory cell (Treg) dynamics throughout the lifetime, based on a model by Baltcheva. We show that our initial simulation produces an inversion between

precursor and mature Tregs at around 20 years of age, though the output differs significantly from the original laboratory dataset. Secondly, this report discusses

development of the model to incorporate new data from a cross-sectional study of healthy blood donors addressing balance between Tregs and Th17 cells with novel markers for Treg. The potential for simulation to add insight into immune aging is discussed.

Item Type: Book Section
Additional Information: The final publication is available at link.springer.com
Schools/Departments: University of Nottingham UK Campus > Faculty of Science > School of Computer Science
Depositing User: Aickelin, Professor Uwe
Date Deposited: 18 Jun 2013 10:47
Last Modified: 13 Sep 2016 19:31
URI: http://eprints.nottingham.ac.uk/id/eprint/2027

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