Phase-amplitude descriptions of neural oscillator models

Wedgwood, Kyle C.A. and Lin, Kevin K. and Thul, Ruediger and Coombes, Stephen (2013) Phase-amplitude descriptions of neural oscillator models. Journal of Mathematical Neuroscience, 3 (2). ISSN 2190-8567

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Abstract

Phase oscillators are a common starting point for the reduced description of many single neuron models that exhibit a strongly attracting limit cycle. The framework for analysing such models in response to weak perturbations is now particularly well advanced, and has allowed for the development of a theory of weakly connected neural networks. However, the strong-attraction assumption may well not be the natural one for many neural oscillator models. For example, the popular conductance based Morris-Lecar model is known to respond to periodic pulsatile stimulation in a chaotic fashion that cannot be adequately described with a phase reduction. In this paper, we generalise the phase description that allows one to track the evolution of distance from the cycle as well as phase on cycle. We use a classical technique from the theory of ordinary differential equations that makes use of a moving coordinate system to analyse periodic orbits. The subsequent phase-amplitude description is shown to be very well suited to understanding the response of the oscillator to external stimuli (which are not necessarily weak). We consider a number of examples of neural oscillator models, ranging from planar through to high dimensional models, to illustrate the effectiveness of this approach in providing an improvement over the standard phase-reduction technique. As an explicit application of this phase-amplitude framework, we consider in some detail the response of a generic planar model where the strong-attraction assumption does not hold, and examine the response of the system to periodic pulsatile forcing. In addition, we explore how the presence of dynamical shear can lead to a chaotic response.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Science > School of Mathematical Sciences
Depositing User: Thul, Dr Ruediger
Date Deposited: 12 Feb 2013 12:13
Last Modified: 15 Sep 2016 13:10
URI: http://eprints.nottingham.ac.uk/id/eprint/1896

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