Building oscillations bottom up: elemental time scales of intracellular calcium dynamics

Thul, Ruediger and Falcke, Martin (2007) Building oscillations bottom up: elemental time scales of intracellular calcium dynamics. In: Analysis and control of complex nonlinear processes in physics, chemistry and biology. World Scientific lecture notes in complex systems (5). World Scientific, River Edge, NJ, pp. 293-324. ISBN 9789812705839

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Abstract

We analyze the elemental time scale of intracellular calcium dynamics. It is determined by the time course of Ca2+ puffs, which represent the fundamental quantum of Ca2+ release from intracellular storage compartments. Since Ca2+ puffs are truly random, we propose a novel master equation and corresponding Fokker-Planck equations. Our results demonstrate that puff initiation can be mapped to an escape process. The stochastic fraction of puff periods is identified with mean first passage times. We find that the discrete character of release sites represents a necessary condition for puff initiation. A continuous modeling of the number of open channels does not allow Ca2+ puffs in the relevant part of the parameter space.

Item Type: Book Section
Additional Information: From: Analysis and control of complex nonlinear processes in physics, chemistry and biology, L. Schimansky-Geier, B. Fiedler, J. Kurths, E. Schöll (editors), Copyright @ 2007, World Scientific. With permission from World Scientific Publishing Co. Pte. Ltd.
Schools/Departments: University of Nottingham UK Campus > Faculty of Science > School of Mathematical Sciences
Depositing User: Thul, Dr Ruediger
Date Deposited: 07 Jan 2013 09:54
Last Modified: 20 May 2016 17:34
URI: http://eprints.nottingham.ac.uk/id/eprint/1764

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