Persistence of pro-arrhythmic spatio-temporal calcium patterns in atrial myocytes: a computational study of ping waves

Thul, Ruediger and Coombes, Stephen and Bootman, Martin D. (2012) Persistence of pro-arrhythmic spatio-temporal calcium patterns in atrial myocytes: a computational study of ping waves. Frontiers in Physiology, 3 . p. 279. ISSN 1664-042X

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Abstract

Clusters of ryanodine receptors within atrial myocytes are confined to spatially separated layers. In many species, these layers are not juxtaposed by invaginations of the plasma membrane (transverse tubules; 'T-tubules'), so that calcium-induced-calcium signals rely on centripetal propagation rather than voltage-synchronized channel openings to invade the interior of the cell and trigger contraction. The combination of this specific cellular geometry and dynamics of calcium release can lead to novel autonomous spatio-temporal calcium waves, and in particular ping waves. These are waves of calcium release activity that spread as counter-rotating sectors of elevated calcium within a single layer of ryanodine receptors, and can seed further longitudinal calcium waves. Here we show, using a computational model, that these calcium waves can dominate the response of a cell to electrical pacing and hence are pro-arrhythmic. This highlights the importance of modeling internal cellular structures when investigating mechanisms of cardiac dysfunction such as atrial arrhythmia.

Item Type: Article
Additional Information: This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
Schools/Departments: University of Nottingham UK Campus > Faculty of Science > School of Mathematical Sciences
Identification Number: https://doi.org/10.3389/fphys.2012.00279
Depositing User: Thul, Dr Ruediger
Date Deposited: 21 Dec 2012 11:43
Last Modified: 16 Sep 2016 03:53
URI: http://eprints.nottingham.ac.uk/id/eprint/1762

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