Manufacture and characterisation of bioresorbable fibre reinforced composite rods and screws for bone fracture fixation applications

Felfel, Reda (2013) Manufacture and characterisation of bioresorbable fibre reinforced composite rods and screws for bone fracture fixation applications. PhD thesis, University of Nottingham.

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Abstract

Bioresorbable implants are an attractive alternative to metallic bone fixation devices and offer potential to eliminate some of the clinical challenges with the latter. This work explores the manufacturing of fully bioresorbable fibre-reinforced composite rods and screws for such applications. Poly lactic acid (PLA) and phosphate glass fibres (PGF) were combined to provide mechanical reinforcement and biocompatibility characteristics. Aligned and randomly reinforced PLA/PGF composites were prepared by compression moulding prior to thermomechanical deformation into rod and screw forms. In vitro degradation and mechanical properties retention were investigated in phosphate buffered saline (PBS) at 37°C. The composite rods and screws exceeded published data for bioresorbable implants in their virgin state and were towards the upper range of cortical bone properties. The properties reduced rapidly in an aqueous medium and this was attributed to matrix plasticisation and fibre/matrix disbonding. The degraded samples maintained strength and stiffness close to the lower limits of the cortical bone. Water uptake and mass loss for composites exceeded equivalent values for PLA alone due to water wicking at the fibre/matrix interface. Ion release tests correlated linearly with mass loss profiles confirming that the dominant degradation mechanism was fibre dissolution. The PLA/PGF composites also exhibited good biocompatibility to human osteosarcoma and human mesenchymal stem cells.

Item Type: Thesis (University of Nottingham only) (PhD)
Supervisors: Ahmed, I.
Parsons, A.
Rudd, C.D.
Keywords: Biomedical materials, Fracture fixation, Orthopaedic implants, Fibre-reinforced composite rods and screws
Subjects: R Medicine > R Medicine (General) > R855 Medical technology. Biomedical engineering. Electronics
Faculties/Schools: UK Campuses > Faculty of Engineering
Item ID: 14379
Depositing User: EP, Services
Date Deposited: 02 Jul 2014 09:40
Last Modified: 13 Sep 2016 23:06
URI: http://eprints.nottingham.ac.uk/id/eprint/14379

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