Proteomic studies of an explant model of equine articular cartilage in response to pro-inflammatory and anti-inflammatory stimuli
Williams, Adam (2014) Proteomic studies of an explant model of equine articular cartilage in response to pro-inflammatory and anti-inflammatory stimuli. PhD thesis, University of Nottingham.
Osteoarthritis (OA) is characterised by cartilage degradation, inflammation and pain within synovial joints. OA is a major cause of morbidity in the elderly human population and in companion animals such as horses. Changes in expression and activity of pro-inflammatory cytokines, chemokines and catabolic mediators contribute towards OA progression, which can be studied using in vitro culture models and proteomic approaches. This project studied the secretome from an in vitro model of equine articular cartilage, aiming to develop understanding of cartilage biology and degradative processes. These studies also aimed to identify protein markers relevant to this explant model for screening anti-inflammatory properties of novel therapeutics.
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