The design and synthesis of MRI contrast agents for imaging cancer and hypoxia
Grimes, Eleanor F. (2014) The design and synthesis of MRI contrast agents for imaging cancer and hypoxia. PhD thesis, University of Nottingham.
The aim of this thesis was to develop a series of gadolinium(III) contrast agents based on the DOTA and AAZTA molecules used widely in the literature that will locate preferentially in hypoxic tumour cells. Three contrast agents were synthesised with alkyne tags, by adapting compounds already produced in the literature.
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