Synthesis of nanomaterials for biomedical applications

Tang, Selina Vi Yu (2014) Synthesis of nanomaterials for biomedical applications. PhD thesis, University of Nottingham.

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The field of nanotechnology is growing vastly, both as a field of research and in commercial applications. This rapid growth calls for synthesis methods which can produce high quality nanomaterials, while being scalable.

This thesis describes an investigation into the use of a continuous hydrothermal reactor for the synthesis of nanomaterials, with potential use in three different biomedical applications – bone scaffolds, fluorescent biomarkers, and MRI contrast agents.

The first chapter of this thesis provides an overview of nanotechnology: the advantages of nanoscale, the commercial industries which can benefit, and the predominant methods currently used to produce nanomaterials. Some advantages and drawbacks of each synthesis route are given, concluding with a description of the Nozzle reactor – the patented technology used for nanomaterial synthesis in this Thesis. Chapter 2 then focusses on the characterisation techniques used in this thesis, detailing the principles of how data is obtained, as well as highlighting the limitations of each method.

With the background information in place, chapters 3, 4 and 5 describe more specific nanomaterials and how they can be applied to each of the aforementioned biomedical fields. These chapters provide the technical details of how various nanomaterials can be synthesised using the Nozzle reactor, and the structural data (crystallinity, particle size) obtained from these samples. Furthermore, the functional properties of these nanomaterials are tested and the results, along with a discussion of any trends, are presented.

Finally, this thesis concludes with a summary of the results described and emphasises the key areas where further work can be conducted.

Item Type: Thesis (University of Nottingham only) (PhD)
Supervisors: Lester, E.
Khlobystov, A.
Subjects: R Medicine > R Medicine (General) > R855 Medical technology. Biomedical engineering. Electronics
Faculties/Schools: UK Campuses > Faculty of Engineering
UK Campuses > Faculty of Engineering > Department of Chemical and Environmental Engineering
Item ID: 14101
Depositing User: EP, Services
Date Deposited: 04 Nov 2014 15:19
Last Modified: 14 Sep 2016 11:12

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