Nutrition manipulation during development and its impact of metabolic homeostasis in the adult offspring
Patel, Nikhil (2014) Nutrition manipulation during development and its impact of metabolic homeostasis in the adult offspring. PhD thesis, University of Nottingham.
Latest epidemiological data suggests 1.5 billion adults worldwide are either overweight or obese. With increasing weight and obesity, adipocytes increase in size. The enlargement of adipocytes has been associated with low grade chronic inflammation via elevated adipokine secretion. Previous epidemiological studies in humans and experimental studies in animals have shown that during different periods of pregnancy (gestation) the offspring that are born to maternal nutritional manipulation are more susceptible to developing metabolic diseases in later adult life. Therefore, the aim of this thesis was to investigate the role of maternal nutritional manipulation on adipose tissue depots and in particular the consequences the effect on markers of adipokine secretion.
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