Evaluation of a nanoparticle drug delivery vehicle in medulloblastoma and organotypic brain cell cultures
Meng, Weina (2006) Evaluation of a nanoparticle drug delivery vehicle in medulloblastoma and organotypic brain cell cultures. PhD thesis, University of Nottingham.
It has been widely reported that cell culture dimension and microenvironment influence cell proliferation, differentiation, and gene expression, which lead to different interactions between drug delivery systems and cells. The development in evaluation of drug delivery systems has reached the stage where investigations are now concentrating on intracellular uptake and subcellular localization of drug delivery systems.This thesis investigates the use of three-dimensional (3-D) tissue culture models to study how nanoparticles (NPs) may behave in vivo.
Actions (Archive Staff Only)