Synthetic studies towards the cytotoxic marine natural product diazonamide A
Green, Clive P. (1999) Synthetic studies towards the cytotoxic marine natural product diazonamide A. PhD thesis, University of Nottingham.
The thesis describes synthetic studies towards the marine natural product diazonamide A. This unprecedented compound was recently isolated from a colonial ascidian and displays exceptional levels of cytotoxic activity against human cancer cell lines. The Introduction includes an account of how diazonamide A was isolated and its structure determined. This is followed by a summary of the different natural products which have been isolated from ascidians, and highlights the structural similarities between these compounds and diazonamide A. The Introduction concludes with a review of structurally related natural products which concentrates on compounds containing oxazole rings or biaryl bonds.
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