Design and synthesis of indole-thiazole based inhibitors of UDP-galactopyranose mutase
Tie, Ding Yee (2013) Design and synthesis of indole-thiazole based inhibitors of UDP-galactopyranose mutase. MSc(Res) thesis, University of Nottingham.
Tuberculosis, which is caused by the pathogenic bacterium Mycobacteria tuberculosis (MTB), is an infectious disease that remains a significant worldwide health threat. Galactofuranose (Galf) residues play an imperative role in the growth of MTB as it is an essential component in the cell wall of this bacterium. UDP-Galactopyranose mutase UGM) is a flavoenzyme that involved in Galf biosynthesis. It catalyzes the reversible conversion of UDP-galactopyranose (UDP-Galp) to UDP-galactofuranose (UDP-Galf).
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