Campylobacter in farm animals
John, Amy (2011) Campylobacter in farm animals. PhD thesis, University of Nottingham.
Campylobaeter jejuni and C. coli are common causes of acute gastroenteritis in humans that are also associated with Guillain Barre and Miller Fisher syndrome. Poultry and other farm animals are the major sources of these pathogens. In this thesis it was demonstrated that hydrogen has the potential to act as an antioxidant to reduce oxidative stress caused during the growth of C. jejuni HPC5 when grown in a gas replacement jar. Growth in the absence of hydrogen in a modular atmosphere controlled system (MACS) was characterised by an intiallag that could be overcome by adding an antioxidant reagent FBP (10% ferrous sulphate, sodium pyruvate and sodium metabisulphite). Transcriptomic studies revealed that growth in the absence of hydrogen resulted in significant increases in the expression of superoxide dismutase, thiol peroxidase and ribosomal proteins.
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