Identification of novel transcripts of CHRNA7 and CHRFAM7A in airway epithelial cells
Ahmad, Omar Akram Jerjees (2013) Identification of novel transcripts of CHRNA7 and CHRFAM7A in airway epithelial cells. PhD thesis, University of Nottingham.
Background: RNA splicing is a crucial process for delivering the appropriate message for protein synthesis. Most genes are affected by alternative splicing, and among these is CHRNA7. This gene encodes for the nicotinic acetylcholine α7 receptor subunit that is involved in the cholinergic anti-inflammatory pathway. This anti-inflammatory pathway is considered an important part of the human body’s defence line against tissue injury or infection and causative mechanism in COPD.
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