A neural origin for central nervous system germ cell tumours
Tan, Christopher Callum Lee (2013) A neural origin for central nervous system germ cell tumours. PhD thesis, University of Nottingham.
Germ cell tumour (GCT) is the collective term for several subtypes of tumour. GCTs most commonly occur in the testis or ovary around puberty, but they also occur at several non-gonadal locations in the human body. These so-called “extra-gonadal” GCTs have the same histology and protein markers as those that arise at gonadal locations. This observation prompted several hypotheses to explain where these tumours come from. Extragonadal locations include the base of the spine (sacrococcygeal region), the abdomen (retroperitoneum), the chest cavity (mediastinum), and the brain (intracranial). The origin of central nervous system (CNS) GCTs is the main focus of this thesis.
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